Key Publications
Cryo-EM reveals binding of linoleic acid to SARS-CoV-2 spike glycoprotein, suggesting an antiviral treatment strategy
Christine Toelzer, Kapil Gupta, Imre Berger, Christiane Schaffitzel
The free fatty acid–binding pocket is a conserved hallmark in pathogenic β-coronavirus spike proteins from SARS-CoV to Omicron
Christine Toelzer, Kapil Gupta, Sathish K.N. Yadav, Lorna Hodgson, Maia Kavanagh Williamson, Dora Buzas, Ufuk Borucu, Kyle Powers, Richard Stenner, Kate Vasileiou, Frederic Garzoni, Daniel Fitzgerald, Christine Payré, Gérard Lambeau, Andrew D. Davidson, Paul Verkade, Martin Frank, Imre Berger, Christiane Schaffitzel
Pathogen-sugar interactions revealed by universal saturation transfer analysis
Charles J Buchanan, Ben Gaunt, Peter J Harrison, Yun Yang, Jiwei Liu, Aziz Khan, Andrew M Giltrap, Audrey Le Bas, Philip N Ward, Kapil Gupta, Maud Dumoux, Tiong Kit Tan, Lisa Schimaski, Sergio Daga, Nicola Picchiotti, Margherita Baldassarri, Elisa Benetti, Chiara Fallerini, Francesca Fava, Annarita Giliberti, Panagiotis I Koukos, Matthew J Davy, Abirami Lakshminarayanan, Xiaochao Xue, Georgios Papadakis, Lachlan P Deimel, Virgínia Casablancas-Antràs, Timothy D W Claridge, Alexandre M J J Bonvin, Quentin J Sattentau, Simone Furini, Marco Gori, Jiandong Huo, Raymond J Owens, Christiane Schaffitzel, Imre Berger, Alessandra Renieri, GEN-COVID Multicenter Study; James H Naismith, Andrew J Baldwin, Benjamin G Davis
Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein
Oskar Staufer, Kapil Gupta, Jochen Estebano Hernandez Bücher, Fabian Kohler, Christian Sigl, Gunjita Singh, Kate Vasileiou, Ana Yagüe Relimpio, Meline Macher, Sebastian Fabritz, Hendrik Dietz, Elisabetta Ada Cavalcanti Adam, Christiane Schaffitzel, Alessia Ruggieri, Ilia Platzman, Imre Berger & Joachim P. Spatz
Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2
Kapil Gupta, Christine Toelzer, Maia Kavanagh Williamson, Deborah K. Shoemark, A. Sofia F. Oliveira, David A. Matthews, Abdulaziz Almuqrin, Oskar Staufer, Sathish K. N. Yadav, Ufuk Borucu, Frederic Garzoni, Daniel Fitzgerald, Joachim Spatz, Adrian J. Mulholland, Andrew D. Davidson, Christiane Schaffitzel & Imre Berger
The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour.
A Sofia F Oliveira A, Deborah K Shoemark, Amaurys Avila Ibarra, Andrew D Davidson, Imre Berger, Christiane Schaffitzel & Andrew J Mulholland
The SARS-CoV-2 spike protein: balancing stability and infectivity
Imre Berger, Christiane Schaffitzel
